Fig. 9: Excessive suppression of cholesterol promotes tumor growth in elderly mice. | Nature Communications

Fig. 9: Excessive suppression of cholesterol promotes tumor growth in elderly mice.

From: Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Fig. 9: Excessive suppression of cholesterol promotes tumor growth in elderly mice.The alternative text for this image may have been generated using AI.

A Schematic design of the KLN-205 cells allograft model. Four groups: PBS, low-dose simvastatin (2.5 mg/kg), medium-dose simvastatin (25 mg/kg), and high-dose simvastatin (50 mg/kg) (n = 5) (Created in BioRender. Major, Z. (2024) https://BioRender.com/z47q423). B The content of plasm cholesterol components were measured by the Cholesterol Assay Kit in the four groups. C The content of total cholesterol, free cholesterol, and cholesterol ester components in the Tregs were measured by the Cholesterol Assay Kit in the four groups. D The mRNA expression of SOAT2 in the intratumoral Tregs was monitored by quantitative RT-PCR using gene-specific primers and probes. E–G Representative images of subcutaneous tumors (E), tumor volume (F), and tumor weight (G) in indicated groups. H The mechanism of SOAT2 exerts immunosuppression in elderly LSCC patients (Created in BioRender. Major, Z. (2022) https://BioRender.com/f54k103). Data represented means ± SD. Statistical difference was evaluated by one-way ANOVA test (B, C, D, F, G). Source data are provided as a Source Data file. (*P < 0.05; **P < 0.01; ***P < 0.001; ns no significance).

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