Fig. 1: Characterization of algae-based biohybrid microrobot nebulizer platform for inhalable lung delivery.
From: Inhalable biohybrid microrobots: a non-invasive approach for lung treatment
a A nebulizer is used to aerosolize M. pusilla green algae-based biohybrid microrobots. The aerosol droplets are inhaled into the lungs where the biohybrid microrobots actively distribute. b Pseudo-colored SEM image of an algae robot. Scale bar, 500 nm. c Brightfield (BF) and Cy5 fluorescent channel merged images showing aerosol particles loaded with algae robots (in red). Scale bars, 5 µm (main) and 2 µm (zoomed-in). d Representative aerodynamic diameter size distribution of aerosol particles loaded with algae robots. e Heat map displaying the motility ratio of algae robots in simulated lung fluid (SLF) after nebulization. The study was conducted at nebulizer air flow rates at 4, 6, 8, and 10 L min−1 and green algae robot concentrations of 107, 108, 109, and 1010 mL−1 (n = 6). Independent experiments were performed (n = 3) for (b and c) with similar results.
