Fig. 2: Endogenous remyelination is driven by recent oligodendrocyte loss.

A, C, E OL gain rate (as a percentage of baseline OLs per day) at 14 days is weakly correlated with OL number (as a percentage of baseline OLs) at 7 days (A), correlated with cumulative OL loss (as a percentage of baseline OLs) at 7 days (C), and strongly correlated with OL loss rate (as a percentage of baseline OLs per day) at 7 days (E). B, D, F OL gain rate at 7, 14, 21, or 28 days does not correlate well with OL number at −14, −11, −7, 0, 4, 7, 11, 14, or 18 days (B), correlates well with cumulative OL loss at several days during remyelination (D), and correlates best with OL loss rate approximately 7 days prior (F). Dot size represents R² magnitude. R² value is indicated for the strongest significant correlation. Dark blue dots signify significant correlations (linear regression, n = 15) given Bonferroni correction for multiple comparisons, p < 0.05/10 = 0.005 (B) or p < 0.05/13 = 0.0038 (D, F). G OL gain rate at 7, 14, 21, and 28 days is best predicted by OL loss rate 4, 7, 7, and 7 days prior, respectively. H Plot of strongest correlations from (F): OL gain rate at 7, 14, 21, and 28 days vs. OL loss rate at 4, 7, 14, and 21 days, respectively (black, light blue, dark blue, yellow, respectively). Dashed line of equality. In (A), linear regression (F(1, 13) = 5.22, n = 15). In (C), linear regression (F(1, 13) = 14.24, n = 15). In (E), linear regression (F(1, 13) = 37.20, n = 15). Line of best fit ± 95% CI in (A, C, E); n=mice. See Supplementary Data 1 for statistical details and Source Data file for source data. OL = oligodendrocyte.