Fig. 1: Overview of NdasCDO-catalysed reaction.
From: Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Top: CDP substrate can contain one (if cyclic dipeptide contains a glycine) or two amino acid side chains which can undergo oxidation. Binding of CDP substrate is followed by fast peptide oxidation then by slow oxidation of the FMN cofactor to regenerate catalytic competent enzyme. Both A and B subunits are required for activity. Bottom: Illustration of two consecutive oxidation events which can take place with some CDP substrates.
