Table 1 Predicted pro-inflammatory biomolecules in the 3hrPlas_PLGA Coronas

From: Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles

Biomolecule

Abbreviation

NaïvePlas_PLGA

3hrPlas_PLGA

3hr/Naïve Fold Change

Hemoglobin alpha/beta#

Hb a/b

7368037972

1.6183E + 10

2.19

Fibrinogen alpha/beta/gamma#

Fb a/b/g

3240853846

5137491963

1.58

Fibronectin

FN1

3038841781

5094975764

1.67

Serum amyloid A-1 protein

Saa1

80273360

909709588

11.33

Thrombospodin-1

THBS1

232968616

902048653

3.87

Cathelicidin antimicrobial peptide

CAMP

9455725

390457198

41.29

Heat shock cognate 71 kDa protein

HSPA8

47700503

88425701

1.85

Serum amyloid A-3 protein

Saa3

4299444

87689417

20.39

Moesin

MSN

12531147

33608958

2.68

Histone H2, H3, H4

H2,H3,H4

4117818

14248749

3.46

Neutrophil elastase

ELANE

5827421

13787790

2.36

Peroxiredoxin-1

PRDX1

2254814

7266159

3.22

Annexin A2

ANXA2

1486325

6293004

4.23

Heat shock protein 60

HSPD1

1872207

3309279

1.76

S100 calcium-binding protein A9#

S100A9

0

1967366

NA

Heat shock 70 kDa protein 1A

Hspa1a

0

1637649

NA

Heat shock protein 90 alpha/beta

HSP90aa1/b1/ab1

8455798

32192904

3.80

Caveolin-1

CAV1

45650

695619

15.23

Histidine-tRNA ligase

HARS1

55924

294886

5.27

Colfosceril Palmitate

PC 16:0/16:0

62107

103352

1.66

  1. Values displayed as average abundance (n = 3). # = Biomolecules evaluated in subsequent testing.