Fig. 6: Identification of marker peaks and transcription factors (TFs) in each cell type in epithelial lineage. | Nature Communications

Fig. 6: Identification of marker peaks and transcription factors (TFs) in each cell type in epithelial lineage.

From: Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients

Fig. 6

a Marker peaks for each cell type in epithelial lineage. Accessibility is scaled in each column across cell types. b Transcription factors enriched in each cell type. Enrichment was assessed using the hypergeometric test (one-sided), with p-values adjusted using the Bonferroni correction to account for multiple comparisons. c Differentially accessible regions in AC EC2 vs TI EC1 and pouch EC2 vs pouch EC1. d Stacked violin plot shows the RNA expression of different TFs in each enterocyte group. e Heatmap shows the scaled mean ChromVar TF activity score in each enterocyte group. The score is scaled in each row across enterocyte groups (left). TF activity in EC1 lineage and EC2 lineage along inferred differentiation pseudotime (middle, right).

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