Fig. 7: Construction of TF-gene regulatory network in pouch enterocytes by peak-gene linkages based on multiomic analysis. | Nature Communications

Fig. 7: Construction of TF-gene regulatory network in pouch enterocytes by peak-gene linkages based on multiomic analysis.

From: Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients

Fig. 7

a 31,808 peak-gene links are identified based on the correlation of gene expression and peak accessibility with a correlation score cutoff > 0.6. b Peaks highly correlated with CA2 gene expression show higher accessibility in colon and pouch EC2 enterocytes (highlighted by arrows). c TF-gene regulatory network shows that the TFs (red nodes) are dominating different groups of genes in pouch EC1 and EC2.

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