Table 1 Survival rates of larvae infected with the C. glabrata wild-type and ipi1R70H strains
Treatment | Straina | Survival rate of larvaeb at: | P-valuec | ||
|---|---|---|---|---|---|
24 h | 48 h | 72 h | |||
No drug (saline) | WT | 80.0% (12/15) | 0% (0/15) | N/A | 0.93 |
ipi1R70H | 78.6% (11/14) | 0% (0/14) | N/A | ||
Micafungin (1 μg/larva) | WT | 100% (15/15) | 73.3% (11/15) | N/A | <0.0001 |
ipi1R70H | 100% (14/14) | 0% (0/14) | N/A | ||
Micafungin (4 μg/larva) | WT | 100% (11/11) | 81.8% (9/11) | N/A | 0.54 |
ipi1R70H | 100% (11/11) | 90.9% (10/11) | N/A | ||
No drug (saline) | WT | 87.5% (7/8) | 25.0% (2/8) | 0% (0/8) | 0.63 |
ipi1R70H | 87.5% (7/8) | 12.5% (1/8) | 0% (0/8) | ||
Caspofungin (0.5 μg/larva) | WT | 100% (8/8) | 75.0% (6/8) | 0% (0/8) | 0.015 |
ipi1R70H | 100% (8/8) | 12.5% (1/8) | 0% (0/8) | ||
Caspofungin (1 μg/larva) | WT | 100% (8/8) | 62.5% (5/8) | 0% (0/8) | 0.74 |
ipi1R70H | 87.5% (7/8) | 75.0% (6/8) | 0% (0/8) | ||
Caspofungin (2 μg/larva) | WT | 100% (8/8) | 62.5% (5/8) | 12.5% (1/8) | 0.48 |
ipi1R70H | 100% (8/8) | 75.0% (6/8) | 25.0% (2/8) | ||
Anidulafungin (2 μg/larva) | WT | 100% (7/7) | 28.6% (2/7) | 0% (0/7) | 0.59 |
ipi1R70H | 100% (7/7) | 42.9% (3/7) | 0% (0/7) | ||
Anidulafungin (8 μg/larva) | WT | 100% (7/7) | 42.9% (3/7) | 28.6% (2/7) | 0.67 |
ipi1R70H | 100% (7/7) | 85.7% (6/7) | 14.3% (1/7) | ||
