Fig. 5: MF-ADNC cases with increased tau PTMs exhibit the highest seeding activities. | Nature Communications

Fig. 5: MF-ADNC cases with increased tau PTMs exhibit the highest seeding activities.

From: Early Alzheimer’s Disease with frequent neuritic plaques harbors neocortical tau seeds distinct from primary age-related tauopathy

Fig. 5

Case-by-case correlation of MF a–c and HP d–f brain homogenate (BH) seeding doses and post-translational (PTM) immunoreactivities normalized to total protein staining. Each point represents a single case (ADNC n = 21, PART n = 17) with average immunoreactivity and standard deviation over 3 replicates and average log10SD50 determinations (1-3 replicates). The logarithmic regression model fits the ADNC and PART cases and associated R2 values are displayed. High ADNC cases (red, n = 3 for MF, n = 2 for HP, Supplementary Table 4) follow the same relationship, and R2 values with their addition to the modeled cohort are also displayed. g Mapping of MF-ADNC (n = 21) and MF-PART (n = 17) BH log10SD50s across Braak stage and CERAD scores. High ADNC (Braak VI, n = 7) samples are included for comparison. All statistical tests in this figure are two-sided.

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