Fig. 6: Tau seeding and select post-translational modifications (PTMs) associate with Aβ neuritic plaque density and differentiate Alzheimer’s Disease neuropathologic change (ADNC) from primary age-related tauopathy (PART). | Nature Communications

Fig. 6: Tau seeding and select post-translational modifications (PTMs) associate with Aβ neuritic plaque density and differentiate Alzheimer’s Disease neuropathologic change (ADNC) from primary age-related tauopathy (PART).

From: Early Alzheimer’s Disease with frequent neuritic plaques harbors neocortical tau seeds distinct from primary age-related tauopathy

Fig. 6

Graphical depiction summarizing comprehensive measurements of tau seeding activity and select PTMs (i.e. pS202/pT205, pT217, and C-terminus) in hippocampus and neocortex. Tau seeding in hippocampus (HP) and midfrontal cortex (MF) increases with disease progression and overall tau NFT Braak stage in ADNC and PART cases. However, Aβ neuritic plaque density significantly relates to increased seeding in MF ADNC compared to MF PART. Higher seeding of ADNC is associated with increased levels of select tau PTMs. This suggests a model in which neuritic plaque-associated processes modify ADNC tau seeding specifically in neocortex and contribute to greater cognitive dysfunction observed in late-stage AD versus PART. Brain image created in Biorender. Kraus, A. (2024) https://BioRender.com/s84o442.

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