Fig. 1: Blimp1 mutants display impaired uterine remodelling at post-partum stages following embryo death. | Nature Communications

Fig. 1: Blimp1 mutants display impaired uterine remodelling at post-partum stages following embryo death.

From: The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse

Fig. 1: Blimp1 mutants display impaired uterine remodelling at post-partum stages following embryo death.

a Decidual swellings (arrows) are present in 9.5 days post-coitum (dpc) Blimp1 mutant uteri despite the absence of a viable embryo. b Epithelialization of the decidual surface and residual parietal trophoblast cells visualised by pan-cytokeratin immunostaining (n = 3). c The failure of Blimp1 mutants to correctly remodel the luminal epithelium post-partum day 5 (PP5) leads to the formation of cystic structures (purple arrows), flanked by cellular masses containing cytokeratin-positive pTGC-like cells (n = 3). Dotted lines distinguish ovaries from the uteri. WT wild type, Mut mutant, UL uterine lumen, M mesometrial, AM antimesometrial. Scale bars = a, c 4 mm (left panels), 1 mm (right panels), b 100 μm, 50 μm (magnified panel).

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