Fig. 2: Wild type decidua display dramatic changes in the pattern of Blimp1 expression 14 hours post RU486 treatment. | Nature Communications

Fig. 2: Wild type decidua display dramatic changes in the pattern of Blimp1 expression 14 hours post RU486 treatment.

From: The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse

Fig. 2: Wild type decidua display dramatic changes in the pattern of Blimp1 expression 14 hours post RU486 treatment.

a Reduced cell-cell contact and accumulation of erythrocytes at the periphery of decidual regions (H&E RU486 panel) in wild type 6.0 dpc decidua (n = 3) within 14 h of RU486 treatment (150 μg, IP). Increased Blimp1 expression in the layer of densely packed stromal cells adjacent to these regions. The zone of Blimp1 expression is marked with a dotted line in higher power images. Conversely, Blimp1 immunostaining is reduced in the decidualised stroma surrounding the embryo. b By 9.0 dpc RU486 treated wild type decidua (n = 6) display more dramatically reduced levels of Blimp1 expression, while displaying markedly increased levels of Blimp1 in the outermost decidual layer. Arrows indicate embryonic visceral yolk sac. E = embryo. Scale bars = a, b 100 μm, 10 μm or 50 μm (magnified panels).

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