Fig. 4: RU486 treatment of Blimp1 mutant females fails to cause decidual detachment. | Nature Communications

Fig. 4: RU486 treatment of Blimp1 mutant females fails to cause decidual detachment.

From: The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse

Fig. 4

a RU486 administration fails to induce alterations in cellular architecture. Dotted lines in higher power images mark the equivalent zone of increased Blimp1 expression seen in wild type 6.0 dpc deciduae (n = 3) following RU486 treatment. b Wild type and mutant uteri 72 h post RU486 administration of 5.5 dpc females. Dotted lines distinguish ovaries from the uteri, while arrows indicate the decidual remnants or deciduae (purple arrows). c Histological sections of wild type (n = 3) and mutant deciduae (n = 3) 72 h post RU486 injection. In Blimp1 mutants, deciduae fail to detach and cytokeratin positive pTGC cells remain detectable. WT wild type, Mut mutant, M mesometrial, AM antimesometrial, dec decidua. Scale bars = a 500 μm, 50 μm (magnified panels), b 4 mm or c 1 mm, 50 μm (magnified panels).

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