Fig. 6: PSmad1/5/9 and Mmp10 expression in 6.0 dpc decidual samples 14 h post RU486 treatment. | Nature Communications

Fig. 6: PSmad1/5/9 and Mmp10 expression in 6.0 dpc decidual samples 14 h post RU486 treatment.

From: The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse

Fig. 6

a In wild type controls (n = 3), nuclear Smad1/5/9 staining is predominantly observed in the SDZ, whereas in mutants (n = 3), the cells immediately surrounding the embryo are also positive. Staining is substantially reduced in RU486-treated WT but not mutant. b Compared to wild type controls (n = 4), Mmp10 is strongly up-regulated in RU486 treated wild type decidual cell populations immediately adjacent to the embryo implantation site and in the peripheral layer. Expression is unaffected in RU486 treated mutant samples (n = 3). PDZ primary decidual zone, SDZ secondary decidual zone, E embryo. Scale bars = a 500 μm, 50 μm (magnified panels), b 500 μm, 100 μm (magnified panels).

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