Fig. 5: Integration results of INSTINCT on samples with varying sequencing depths from the spatial-ATAC-seq ME dataset. | Nature Communications

Fig. 5: Integration results of INSTINCT on samples with varying sequencing depths from the spatial-ATAC-seq ME dataset.

From: INSTINCT: Multi-sample integration of spatial chromatin accessibility sequencing data via stochastic domain translation

Fig. 5

a Comparison of the log-normalized fragment counts and the TSS ratios across the three samples from the spatial-ATAC-seq ME dataset. The center line, box limits, and whiskers represent the median, upper and lower quartiles, and the maximum and minimum values within 1.5 times the interquartile range, respectively. n = 2500 spots for each unfiltered slice. b UMAP visualizations of the raw data and the integrated results of INSTINCT, with spots colored by slice affiliation. c UMAP visualization of the clustering results of INSTINCT, with spots colored based on identified clusters. d Spatial arrangement of clusters, with spots colored according to their specific clusters. e Motif enrichment analysis results for the three slices, with spots colored based on the motif enrichment score with respect to specific motifs. f Spatial arrangement of DEGs for identified clusters based on their expression levels. Source data are provided as a Source Data file.

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