Fig. 7: Telomere length homeostasis during incrosses of Terth/h mice. | Nature Communications

Fig. 7: Telomere length homeostasis during incrosses of Terth/h mice.

From: Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length

Fig. 7

a Breeding schemes. Terth/h progeny from G4, G4.8, and G4.14 Terth/- parents were successively incrossed. b Relative telomere signals. Telomere signals were determined by Flow-FISH and normalized to that of wildtype C57BL/6 J mice (50 kb). n ≥ 3. c TRF analysis. A longer exposure is shown in Supplementary Fig. 8b. d Body weight. e Litter sizes. f Testis weight. Each data point represents one animal. Means ± SDs are shown in panels b, & d–f. Source data for panels b–f are provided as Source Data files.

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