Fig. 7: ECO kidney transplants in human decedent. | Nature Communications

Fig. 7: ECO kidney transplants in human decedent.

From: Enzymatic conversion of blood group B kidney prevents hyperacute antibody-mediated injuries in ABO-incompatible transplantation

Fig. 7: ECO kidney transplants in human decedent.The alternative text for this image may have been generated using AI.

a Schematic overview of ECO kidney transplantation in human decedent. Following a 3 h treatment with 10 μg/mL B-zyme during HMP, a type B kidney was enzymatically converted to type O and subsequently transplanted into a type O brain-dead recipient. b Gross view of the ECO kidney during enzymatic conversion and operation. The ECO kidney turned pink after revascularization. c Photographs of the ECO graft after transplantation. The allograft survived for 63 h. d Anti-B antibody titers in recipients (n = 1). e Urine output from native kidneys and ECO grafts after transplantation (n = 1). The ECO kidney produced 125 mL of urine within the first 24 h. f Concentration of urinary kidney injury markers in ECO allograft (n = 1). Source data are provided as a Source Data file. ECO enzyme converted O, IS immunosuppressant, h hour, HMP hypothermic machine perfusion, NGAL neutrophil gelatinase-associated lipocalin, KIM-1 Kidney Injury Molecule-1.

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