Fig. 2: Gene expression and plasma lipids in LXRα W441F mice. | Nature Communications

Fig. 2: Gene expression and plasma lipids in LXRα W441F mice.

From: A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis

Fig. 2

Liver RNA, intestine RNA and plasma were isolated from 11–12 week old control (W/W), heterozygous mutant (W/F), and homozygous mutant (F/F) W441F mice maintained on normal chow diet. a–f Gene expression measured by real-time PCR as described in the Methods section. *Statistically significant difference between control and mutant mice determined by one-way ANOVA (p ≤ 0.05; n = 6 W/W/sex, n = 6 W/F/sex. n = 6 F/F females, n = 4 F/F males). g–i Plasma triglycerides, cholesterol, and glucose were measured as described in the Methods section. *Statistically significant difference between control and mutant mice determined by one-way ANOVA (p ≤ 0.05; n = 12 W/W/sex, n = 17 W/F females, n = 18 W/F males, n = 12 F/F females, n = 13 F/F males). Boxes extend from the 25th–75th percentiles. The center line in the middle of the boxes represents the median. Whiskers extend from the lowest to the highest point. Source data are provided as Source Data file.

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