Fig. 7: Liver gene expression in LXRα W441F mice fed the MASH diet.

Female and male 11–12 week old control (W/W), heterozygous mutant (W/F), and homozygous mutant (F/F) W441F mice were fed the MASH diet. A subset of mice was sacrificed after 2 weeks. The remaining mice were maintained on the MASH diet for an additional 2 weeks and treated with vehicle or 10 mg/kg T0901317 daily by oral gavage as described in the Methods section. a PCA analysis of RNA-Seq data using liver RNA isolated from male mice (n = 4/group). b–i Gene expression in livers from female mice measured by real-time PCR as described in the Methods section. Gene expression was also measured in an independent cohort of 11–12 week old female mice maintained on normal chow. Numbers in b and c represent the fold induction by T0901317 in F/F mice. *Statistically significant difference between control and mutant mice in the same treatment group; **statistically significant difference between vehicle and T0901317 treated mice of the same genotype determined by two-way ANOVA (p ≤ 0.05, n = 6/group). Boxes extend from the 25th–75th percentiles. The center line in the middle of the boxes represents the median. Whiskers extend from the lowest to the highest point. Source data are provided as Source Data file.