Fig. 6: Cartoon illustration of TyrRS-mediated TLS aminoacylation reaction and TLS interactions with elongation factors to harness host translational machinery. | Nature Communications

Fig. 6: Cartoon illustration of TyrRS-mediated TLS aminoacylation reaction and TLS interactions with elongation factors to harness host translational machinery.

From: Structural insights into dynamics of the BMV TLS aminoacylation

Fig. 6

Upon binding with TyrRS, BMV TLS undergoes significant conformational rearrangements, which allow it to be recognized by TyrRS to charge with Tyr, mimicking a tRNA function. The Tyr-charging TLS then binds with EF1α or EF2 to manipulate the host’s translational machinery to its advantage. Created in BioRender. N′N′, OY. (2025) https://BioRender.com/q47d213.

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