Fig. 2: Minimal energy principles predict differences in protein synthesis location along specific parameter dimensions.
From: How energy determines spatial localisation and copy number of molecules in neurons
A–E Effect of mRNA (red) and protein (blue) parameters on the predicted preference of synthetic protein species for dendritic mRNA with mRNA transport vs. somatic mRNA on a 1000 μm long dendrite. In each panel, one parameter is varied along the x-axis: A mRNA half-life, B length of non-coding regions relative to coding sequence length, C maximal number of proteins per spine, D protein half-life, E protein size in amino acids. For each synthetic protein species, the total costs when using somatic mRNA were divided by those with dendritic mRNA and normalised with the corresponding ratio in the middle category. Bars show the population median.
