Fig. 7: Internalized Als3 modulates inflammasome signaling and apoptosis.
From: Fungal Als proteins hijack host death effector domains to promote inflammasome signaling
Als proteins from C. albicans hyphae are internalized into host cells. The specific mechanisms by which Als proteins escape from endosomes remain unknown. Within the cytosol, Als proteins interact with the DEDs of FADD and/or caspase-8, promoting their oligomerization and forming an N-Als/FADD/caspase-8 complex. This complex plays multiple roles in different cell types. It promotes ASC oligomerization in macrophages and inhibits apoptosis in non-immune cells. Consequently, Als not only inhibits apoptosis but also promotes inflammasome signaling. Created in BioRender. Zhou, T. (2025) https://BioRender.com/u12i251.
