Fig. 7: Proviruses associated with viremia in proliferated cell clones have activating chromatin features.

a Heat map demonstrating the odds ratio of proviruses with the listed genetic and epigenetic features. Two different comparisons were made: proviruses associated with (+viremia) or without (-viremia) viremia (left), proviruses among proliferated cell clones associated with (+viremia) or without (-viremia) viremia (right). The odds ratios and the p values were calculated using the two-sided Fisher’s exact test. n.s., P > 0.05. b Log₁₀ transformed chromosomal distance (bp) to the nearest histone modification among +viremia or -viremia provirses. n represents the number of proviruses. c Log₁₀ transformed chromosomal distance (bp) to the nearest transcription start site (TSS) (left), same-direction TSS (middle) and ATAC-peak (right) among +viremia versus -viremia proviruses. n represents the total number of proviruses (left, right) or number of same-orientation proviruses (middle). d Log₁₀ transformed chromosomal distance (bp) to the nearest histone modification of +viremia versus -viremia proviruses among proliferated cell clones. n represents the number of proviruses among proliferated cell clones. e Log₁₀ transformed chromosomal distance (bp) to the nearest transcription start site (TSS) (left), same-direction TSS (middle) and ATAC-peak (right) among +viremia versus -viremia proviruses in proliferated cell clones. n represents the number of proviruses among proliferated cell clones. Horizontal bars represent mean ± SD. n.s., p > 0.05. P values were calculated using the two-tailed Mann-Whitney test (b–e). Source Data a–e.