Fig. 4: Uncovering the single-cell Replication Timing (scRT) of heterogenous cancer cell lines. | Nature Communications

Fig. 4: Uncovering the single-cell Replication Timing (scRT) of heterogenous cancer cell lines.

From: Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression

Fig. 4

a–d Early (green) and late (purple) S-phase cells from MCF-7 (a, b) and S phase FACS-predicted WT HCT-116 (c, d) populations are corrected (b, d) from raw scCNV data (a, c) that display non-replicating (blue) and replicating (green) cells. e, f Chromosome 16 scRT landscapes of MCF-7 (e) and WT HCT-116 (f) cells display minor differences between subpopulations. Bulk replication timing (RT) and pseudo-bulk RT data are displayed in the upper window. Correlations between pseudo-bulk subpopulation scRT and bulk RT data for MCF-7 (g) and WT HCT-116 (h) cells. Source data are provided as a Source Data file.

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