Fig. 6: The scRT atlas reveals cell-type specific relationships of DNA replication. | Nature Communications

Fig. 6: The scRT atlas reveals cell-type specific relationships of DNA replication.

From: Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression

Fig. 6

Spearman correlations between the 41 scRT pseudo-bulk profiles extracted from human cell lines, patient tumours and patient-derived xenograft (PDX) samples. Samples were ordered by hierarchical clustering using the second version of Ward’s minimum variance method (Ward.D2). Cell subpopulations from the same sample are indicated with an S after the sample name (e.g. S1, S2). Cell origins (tissue) are given in brackets after the sample name. PDX samples are identified as sample_numberXmouse_passage. hESC: human embryonic stem cells; RPE: retinal pigment epithelial cells; TNBC: triple-negative breast cancer; ERpos: oestrogen receptor positive; PDX: patient-derived xenograft; HGSOC: high-grade serous ovarian carcinoma; hTERT: human telomerase reverse transcriptase. FNA: fine-needle aspiration (cell collection technique). Source data are provided as a Source Data file.

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