Fig. 3: Predicting SR parameters for combined stimuli.
From: Parameterized resetting model captures dose-dependent entrainment of the mouse circadian clock
a Prediction model for mixed stimuli based on SR parameters for each single stimulus. b Predicted SR amplitude of the combination of different types of stimuli: dexamethasone (DEX) and phorbol 12-myristate 13-acetate (PMA), DEX and forskolin (FK), and cobalt chloride and lithium chloride. c Predicted SR phase for the combination of different types of stimuli. d Prediction model for mixed stimuli based on the equivalent concentrations. e Prediction of the SR amplitude for the combination of the same types of stimuli (hydrocortisone (HYD) and corticosterone (CORT)). Red and blue points indicate the estimated amplitude using the sum of equivalent concentrations (a) and SR parameters (d), respectively. Blank circles indicate the results of the combination of different types of stimuli (b). f Measured and predicted PRCs for mixed stimuli (black points), and predicted PRCs based on the predicted SR parameters (red curves). PRC phase response curve, SR singularity response.
