Table 3 Summary of geometric mean MPXV titres in various organs

From: Strong and early monkeypox virus-specific immunity associated with mild disease after intradermal clade-IIb-infection in CAST/EiJ-mice

MPXV scarification

 

12 dpi

8 dpi

 

MPXV

Clade IIa

Clade IIb

Clade IIa

Clade IIb

 

Infection dosage

2 × 104

2 × 105

2  × 104

2 × 105

2 × 105

2 × 105

PFU

mice

 total

n = 8

n = 8

n = 8

n = 7

n = 4

n = 4

 

 survived

n = 5

n = 5

n = 8

n = 3

n = 4

n = 4

 

lung

1.2

5.0 × 102

nd

29.3

2.8 × 102

61.7

PFU/ml

spleen

3.6

3.7 × 102

0.2 (*)

1.4 × 102

1.3 × 103

2.6 × 102

PFU/ml

liver

1.5

3.9 × 103

nd

2.8 × 103

8.4

5.0

PFU/ml

o-swab

 day 4

nd

nd

0.2 (*)

nd

nd

nd

PFU/ml

 final

4.4 × 102

3.1 × 105

0.3

1.0

1.7 × 104

29.4

PFU/ml

s-swab final

7.4 × 102

6.8 × 104

83.6

4.7 × 103

4.2 × 105

5.3 × 104

PFU/ml

  1. CAST/EiJ were infected with 2 × 104 or 2 × 105 PFU of either MPXV clade IIa or IIb for an infection interval of 12 days and with 2 × 105 PFU of either MPXV clade IIa or IIb for 8 days. Organs from day of necropsy and swab samples from day 4 and from day of necropsy (final) were collected and analysed for geometric mean infectious virus titres using plaque assays (data from Figs. 4 and 5). * Only one infected animal revealed infectious virus. nd = not detected.
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