Fig. 3: Cryo-EM structures of nucleosomes and chromatosomes connected by the BAF-Lamin A/C IgF complexes.
From: Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes
a Cryo-EM map of the BAF-Lamin A/C IgF-nucleosome complex of fraction 2 in Fig. 1 (panel b). Histones and DNA are colored light blue and gold, respectively. BAFs and Lamin A/C IgFs for the dyad binding and the nucleosome bridging are indicated in the cryo-EM maps. b Structure of the BAF-Lamin A/C IgF-nucleosome complex in panel (a). c Close-up view of the interface between two nucleosomes and the BAF dimer and Lamin A/C IgF. d Cryo-EM map of the BAF-Lamin A/C IgF-H1-nucleosome complex. Histones and DNA are colored light blue and gold, respectively. H1 bound to the nucleosomal dyad, and BAFs and Lamin A/C IgFs involved in the nucleosome bridging are indicated in the cryo-EM maps. e Structure of the BAF-Lamin A/C IgF-H1-nucleosome complex in panel (d).
