Fig. 5: Comparison of gene-expression in brain and blood of Alzheimer’s patients.

a Single-cell RNA-sequencing data from the cortex from the ZEBRA-dataset was used for the comparison of changes in PBMC samples and brain samples. b Fold-changes in PBMCs and cortex of the genes with an adj. p-value < 0.05 (see Methods) in the PBMCs the brain in males. c De-regulation of genes in PBMCs and cortex with an adj. p-value < 0.05 in PBMCs and the brain and an abs. log2 fold-change bigger than 0.6 in the PBMCs (see Methods). d, e Deregulation of the significantly de-regulated genes in all three datasets (see Methods) and the direction of de-regulation in males (d) and females (e) ( + : Up-regulated in all cell-types, -: Down-regulated in all cell-types and *: Mixed signals). Genes are annotated with the context in which they have been previously reported in for Alzheimer’s (see Supplementary Table 3). f Top 10 most frequently enriched or depleted pathways in both brain datasets and in PBMCs and the proportion of cell-types they are enriched/depleted in.