Fig. 3: Scope of N–N axially chiral isoindolinones bearing a quaternary stereocenter.

Reaction conditions: 1 (0.4 mmol), 2 (0.2 mmol), (S)-A4 (5 mol%), toluene (2 mL), −20 °C, 36 h. Isolated yields. ^a0 °C, 72 h. ^bp-Xylene, 25 °C, 24 h.