Fig. 1: 8q24 region screening identified that genomic amplification activated-ZNF252P in diverse cancer types and correlates with clinicopathological characteristics.

A The flow chart of lncRNA screening in 8q24 region. B Top 10 lncRNAs of the CNA~lncRNA in pan-cancer (order according to the average correlation coefficient). C Amplification frequency of ZNF252P in pan-cancer. D ZNF252P expression elevated with copy number amplification rather than copy number deletion in diverse cancers. Data are presented as boxplots with median (middle line), 25th, 75th percentile (box), and 5th and 95th percentile (whiskers), two-tailed Student’s t-test. E The expression of ZNF252P was positively related to its copy number amplification (two-tailed Spearman correlation analysis). F The copy numbers of ZNF252P in tumor tissues were higher than those in paired non-cancerous tissues by qPCR analysis. Data are presented as boxplots with median (middle line), 25th, 75th percentile (box), and 5th and 95th percentile (whiskers), n = 40, two-tailed Student’s t-test. G The copy number of ZNF252P was positively correlated with its expression in NSCLC tissues (two-tailed Spearman correlation analysis). H ZNF252P expression was upregulated in diverse cancers using the TCGA dataset. Data are presented as boxplots with median (middle line), 25th, 75th percentile (box), and 5th and 95th percentile (whiskers), two-tailed Student’s t-test. I Higher ZNF252P predicted a poorer overall survival (OS) in diverse cancers. The log-rank test. J The ZNF252P expression in NSCLC tissues were higher than those in paired non-cancerous tissues by qPCR analysis. Data are presented as boxplots with median (middle line), 25th, 75th percentile (box), and 5th and 95th percentile (whiskers), n = 76, two-tailed Student’s t-test. K Higher ZNF252P was related with advanced TNM stage, two-tailed Student’s t-test. L Higher ZNF252P predicted a poorer overall survival (OS) in 76 NSCLC patients. The log-rank test. Source data are provided as a Source data file.