Fig. 2: ZNF252P promotes cancer cell proliferation and tumorigenicity. | Nature Communications

Fig. 2: ZNF252P promotes cancer cell proliferation and tumorigenicity.

From: 8q24 derived ZNF252P promotes tumorigenesis by driving phase separation to activate c-Myc mediated feedback loop

Fig. 2

A The efficacy of ASO-mediated knockdown and plasmid-mediated overexpression of ZNF252P measured by qPCR analysis. Data are mean ± s.d.; n = 3 independent experiments, one-way ANOVA with Dunnett’s multiple comparisons test (the first three groups) or two-tailed Student’s t-test (the last two groups). B The MTT, (C) colony formation, and (D) EDU assay demonstrated the effect of indicated treatments on cell proliferation. Scale bar 200 μm. Data are representatives or mean ± s.d.; n = 3 independent experiments, one-way ANOVA with Dunnett’s multiple comparisons test (the first three groups) or two-tailed Student’s t-test (the last two groups). E Stably transfected A549 and PC9 cells were injected into nude mice. Growth curves of tumor xenografts and tumor weights were measured. Representative images of tumor sections of H&E and Ki-67 IHC staining. Scale bar 200 μm. Data are representatives or mean ± s.d.; n = 7 mice per group, two-tailed Student’s t-test. Source data are provided as a Source data file.

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