Table 1 siRNA candidates grouped by priority

From: Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Priority

Gene symbol

Entrez gene name

Type

Priority 1

ABCA6

ATP binding cassette subfamily A member 6

Transporter

ABHD17B

Abhydrolase domain containing 17B

Peptidase

ALG10

ALG10, alpha-1,2-glucosyltransferase

Enzyme

CHD8

Chromodomain helicase DNA binding protein 8

Enzyme

CTRC

Chymotrypsin C

Peptidase

LMLN

Leishmanolysin like peptidase

Peptidase

PSMC4

Proteasome 26S subunit, ATPase 4

peptidase

SLC25A32

Solute carrier family 25 member 32

Transporter

SUPT6H

SPT6 homolog, histone chaperone

Transcription regulator

TGFBR2

Transforming growth factor beta receptor 2

Kinase

YY1

YY1 transcription factor

Transcription regulator

Priority 2

BRD4

Bromodomain containing 4

Kinase

EIF1B

Eukaryotic translation initiation factor 1B

Translation regulator

GPX7

Glutathione peroxidase 7

Enzyme

KLF6

Kruppel like factor 6

Transcription regulator

Priority 3

AQP3

Aquaporin 3 (Gill blood group)

Transporter

CLPP

Caseinolytic mitochondrial matrix peptidase proteolytic subunit

Peptidase

FGF2

Fibroblast growth factor 2

Growth factor

HERC2

HECT and RLD domain containing E3 ubiquitin protein ligase 2

Enzyme

MAPKAPK2

Mitogen-activated protein kinase-activated protein kinase 2

Kinase

MFHAS1

Malignant fibrous histiocytoma amplified sequence 1

Other

NEK4

NIMA related kinase 4

Kinase

SLC25A29

Solute carrier family 25 member 29

Transporter