Fig. 2: Jaccard index heatmaps for high genetic risk across trait-specific Best(Pubn) pairs.
From: Instability of high polygenic risk classification and mitigation by integrative scoring
Jaccard indices of similarity calculated for pairs of classification of top 10% risk determined by Best(Pubn) polygenic scores for coronary artery disease, type 2 diabetes mellitus, and major depressive disorder. Scores are ordered chronologically based on date of publication, advancing left to right and bottom to top. The median [interquartile range] Jaccard index for top 10% classification was: A 0.17 [0.13-0.22] for coronary artery disease; B 0.18 [0.15-0.22] for type 2 diabetes mellitus; and C 0.11 [0.08-0.17] for major depressive disorder.
