Fig. 8: Median percentile distributions of Best(Pubn) vs. ChronoAdd(Pubn) across three traits for individuals identified as having high genetic risk by ChronoAdd(PubLast), across genetically inferred ancestry groups.
From: Instability of high polygenic risk classification and mitigation by integrative scoring
Distributions of the median percentile per polygenic score type for individuals classified in the top 10% risk by the ChronoAdd(PubLast) across genetically inferred ancestry groups for each trait: coronary artery disease (CAD), type 2 diabetes mellitus (T2DM), and major depressive disorder (MDD). Genetically inferred ancestry based on k-nearest neighbor approach as European (EUR), African (AFR), admixed American (AMR), and East Asian (EAS). Jaccard index distribution calculated in group EUR for traits A CAD, B T2DM, and C MDD; in group AMR for traits D CAD, E T2DM, and F MDD; in group AFR for traits G CAD, H T2DM, and I MDD; and in group EAS for traits J CAD, K T2DM, and L MDD, respectively. Best(Pubn) indicates the single best trait-specific PRS from each publication Pubn, ordered by date of publication. ChronoAdd(Pubn) indicates polygenic scores generated using the PRSmix framework, wherein all scores from each Pubn were combined with all the scores from all other Pubn published before it using PRSmix.
