Fig. 5: Higher-order interactions between antibiotics in E. coli using drug response data from Tekin et al.40.
From: Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis
A Proportion of E. coli cultures where the sign (positive vs. negative) of the chimeric and additive measures disagree. The sign discordance fraction, or proportion of interactions where the sign of the two measures disagree, increases with the interaction order, consistent with the simulations shown in Fig. 1. B Distributions and Q-Q plots (insets) for the additive (orange) and chimeric (blue) measures for 5th-order interactions. C Scatter plot of median relative growth rates for each 5-way combination of antibiotics across concentration levels and replicates. Dashed horizontal and vertical lines indicate zero additive and chimeric epistasis measures, respectively.
