Fig. 6: Epistasis between protein mutations in eleven different proteins.
From: Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis
A, B Standard deviation of fitness values across all (left) three-, (middle) four-, and (right) five-way tuples of mutations versus the average (A) correlation and (B) sign disagreement fraction of the log-multiplicative measure \(\log {\epsilon }^{M}\) versus the chimeric measure ϵC. Line of best fit is shown as a dashed red line. C, D Log-multiplicative measure \(\log {\epsilon }^{M}\) versus chimeric measure ϵC for the (C) FolA72 and (D) Streptococcus pyogenes Cas9 (SpCas9) nuclease38 proteins. Dashed vertical and horizontal lines indicate zero log-multiplicative and chimeric epistasis measures, respectively.
