Fig. 3: ΔsigH vaccination induces superior antigen-specific responses in BAL post-vaccination. | Nature Communications

Fig. 3: ΔsigH vaccination induces superior antigen-specific responses in BAL post-vaccination.

From: Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate

Fig. 3

Frequencies of CD4+ and CD8+ T cells expressing Interferon-γ (IFNG) (a, f), Tumor Necrosis Factor-α (TNFA) (b, g), IFNG and TNFA (c, h), Granzyme-B (GZMB) (d, i) and Interleukin-17 (IL17) (e, j) in response to Mtb Cell-Wall (CW) fraction in CMs vaccinated with BCG () or ΔsigH () are shown. Frequencies of CD4+ and CD8+ T cells expressing IFNG (k, p), TNFA (l, q), IFNG and TNFA (m, r), GZMB (n, s) and IL17 (o, t) in response to pooled peptide pools of Mtb ESAT6 and CFP10 (EC). Each column represents an individual macaque (n = 5) at weeks 3, 5, and 7 post-vaccination.

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