Fig. 8: SAR247799 protects the endothelial barrier in a lung fibrosis mouse model. | Nature Communications

Fig. 8: SAR247799 protects the endothelial barrier in a lung fibrosis mouse model.

From: S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity

Fig. 8: SAR247799 protects the endothelial barrier in a lung fibrosis mouse model.The alternative text for this image may have been generated using AI.

a Schematic representation of bleomycin-induced mouse fibrosis model with SAR247799 (1 mg/kg) and pirfenidone (300 mg/kg) treatments (intragastric gavage, i.g.). b Body weigh percentage (n = 6). c mRNA level of fibrosis markers α-Sma, Tgf-β, and Col1a1 (n = 6). d hydroxyproline level in lung tissues (n = 6). e Representative images of H&E (n = 6). Scale bar, 2 μm (above),100 μm (below). f Masson’s trichrome staining representative images (n = 6), Scale bar, 2 μm (above),100 μm (below). g Schematic representation of LPS and PPE-induced mouse COPD-like model with SAR247799 (1 mg/kg) treatments (intragastric gavage, i.g.). h Body weigh percentage. i Representative images of H&E staining (n = 6). Scale bar, 2 μm (above),100 μm (below). j Representative images of Periodic acid-Schiff staining (n = 6). Data are presented as mean ± SEM; Statistical analysis: Two-way ANOVA with multiple comparisons (b, h), two-sided Student’s t test (c, d). All biological experiments were repeated three times and yielded consistent results.

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