Fig. 4: Mass spectrometry-based analysis of tau phosphorylation in muscle biopsies. | Nature Communications

Fig. 4: Mass spectrometry-based analysis of tau phosphorylation in muscle biopsies.

From: Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis

Fig. 4

Exemplary spectra and for the identification of p-tau 181 (A) and p-tau 217 (B) in muscle extracts are shown. Both phosphosites were identified in all analysed ALS patients (n = 5) and disease controls (n = 5). C Additional phosphorylation sites were identified in all samples. Two sites, S437 and S438, were identified in a protein region that is not expressed in human CNS tau. Protein regions shown in purple-blue are expressed in adult CNS and other tissues. Protein regions shown in orange, but not in purple-blue, are not expressed in adult CNS. Positions are indicated as the site in the CNS-expressed isoform. Sites outside this isoform are given with respect to the full-length protein. CNS central nervous system, p-tau phosphorylated tau.

Back to article page