Table 1 Summary of conservation at fourfold degenerate sites in mammals

All 4d sites

2,621,118

Mammals^a

21.3

22.8

29.4

26.5

Humans

22.4

23.7

28.3

25.5

Total

544,503 (20.8% of all 4d sites)

Mammals

9.8

9.6

39.9

40.8

Humans

9.6

9.4

39.8

41.1

CpG site (in human genome)

14,195 (2.61% of conserved sites)

Humans

–

–

44.6

55.4

5′ exon edge site (3’ splice site, position +1)

484 (0.09% of conserved sites)

Mammals

12.1

3.3

5.6

79.1

Humans

9.5

5.0

22.7

62.8

5′ exon edge site + 1 (3’ splice site, position +2)

9571 (1.76%)

Mammals

85.5

3.0

4.8

6.7

Humans

80.5

8.3

5.3

6.0

5′ exon edge site + 2 (3’ splice site, position +3)

4167 (0.77%)

Mammals

11.4

4.0

76.8

7.8

Humans

10.9

4.0

71.6

13.5

3′ exon edge site (5’ splice site, position −1)

7341 (1.35%)

Mammals

3.2

2.7

0.5

93.6

Humans

3.1

2.8

14.8

79.3

3′ exon edge site −1 (5’ splice site, position −2)

3883 (0.71%)

Mammals

14.1

34.0

22.1

29.8

Humans

14.7

33.3

23.8

28.2

Alternative splice sites^b

1267 (0.23%)

Mammals

9.9

9.7

33.5

46.9

Humans

9.5

9.8

36.1

44.6