Fig. 4: Crystal structure of P domain in complex with glycan-sensitive bnAbs.
Cartoon view of P domain structures in complex with p60.1 (green; a) and p60.12 (cyan; b) that recognize partially overlapping epitopes at the tip of the P domain dimer (individual protomers colored in light and dark gray). Same view as in Fig. 3a, b. The insets show zoomed views on the interface with a particular focus on the two sidechains of N562. Sidechain oxygen and nitrogen atoms are colored in red and blue, respectively, dashed lines indicate the complex hydrogen binding network stabilizing the high affinity interaction. c + d Top-view of the footprints of human glycan-sensitive bnAbs on the P domain dimer (gray). Sidechain oxygen and nitrogen atoms of N562 are colored in red and blue, respectively, to indicate the position of N3.
