Table 3 Treatment related adverse events
Type of event | Total (n = 100) | Chemo-free (n = 21) | Chemo (n = 79) | |||
|---|---|---|---|---|---|---|
All grades (%) | Grade ≥ 3 (%) | All grades (%) | Grade ≥ 3 (%) | All grades (%) | Grade ≥ 3 (%) | |
Total | 90 (90.0) | 35 (35.0) | 15 (71.4) | 3 (14.3) | 75 (94.9) | 32 (40.5) |
Anemia | 49 (49.0) | 1 (1.0) | 4 (19.0) | 0 (0.0) | 45 (57.0) | 1 (1.3) |
Alopecia | 46 (46.0) | 18 (18.0) | 2 (9.5) | 0 (0.0) | 44 (55.7) | 18 (22.8) |
Neutropenia | 46 (46.0) | 16 (16.0) | 2 (9.5) | 1 (4.8) | 44 (55.7) | 15 (19.0) |
Leukopenia | 41 (41.0) | 5 (5.0) | 2 (9.5) | 0 (0.0) | 39 (49.4) | 5 (6.3) |
ALT increased a | 24 (24.0) | 3 (3.0) | 4 (19.0) | 0 (0.0) | 20 (25.3) | 3 (3.8) |
AST increased a | 18 (18.0) | 2 (2.0) | 5 (23.8) | 0 (0.0) | 13 (16.5) | 2 (2.5) |
Thrombocytopenia | 15 (15.0) | 3 (3.0) | 1 (4.8) | 0 (0.0) | 14 (17.7) | 3 (3.8) |
Hyperglycemia | 15 (15.0) | 0 (0.0) | 4 (19.0) | 0 (0.0) | 11 (13.9) | 0 (0.0) |
Fatigue | 11 (11.0) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 9 (11.4) | 0 (0.0) |
Hemoptysis | 9 (9.0) | 3 (3.0) | 4 (19.0) | 3 (14.3) | 5 (6.3) | 0 (0.0) |
Fever | 9 (9.0) | 1 (1.0) | 2 (9.5) | 0 (0.0) | 7 (8.9) | 1 (1.3) |
Lymphopenia | 9 (9.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 9 (11.4) | 0 (0.0) |
Cough | 8 (8.0) | 3 (3.0) | 2 (9.5) | 1 (4.8) | 6 (7.6) | 2 (2.5) |
Creatinine increase | 8 (8.0) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 6 (7.6) | 0 (0.0) |
Peripheral neuropathy | 7 (7.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 7 (8.9) | 0 (0.0) |
Rash | 6 (6.0) | 1 (1.0) | 1 (4.8) | 0 (0.0) | 5 (6.3) | 1 (1.3) |
Hypertriglyceridemia | 5 (5.0) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 3 (3.8) | 0 (0.0) |
Bacterial pneumonitis | 5 (5.0) | 4 (4.0) | 2 (9.5) | 1 (4.8) | 3 (3.8) | 3 (3.8) |
Hyponatremia | 4 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (5.1) | 0 (0.0) |
Hypokalemia | 4 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (5.1) | 0 (0.0) |
Vomiting | 4 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 4 (5.1) | 0 (0.0) |
Hypoalbuminemia | 4 (4.0) | 0 (0.0) | 1 (4.8) | 0 (0.0) | 3 (3.8) | 0 (0.0) |
Decreased appetite | 4 (4.0) | 0 (0.0) | 1 (4.8) | 0 (0.0) | 3 (3.8) | 0 (0.0) |
Constipation | 3 (3.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 3 (3.8) | 0 (0.0) |
Heart failure | 2 (2.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 2 (2.5) | 1 (1.3) |
Dyspepsia | 2 (2.0) | 0 (0.0) | 2 (9.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Arthralgia | 1 (1.0) | 1 (1.0) | 0 (0.0) | 0 (0.0) | 1 (1.0) | 1 (1.0) |
Diarrhea | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.3) | 0 (0.0) |
Cerebral arterial insufficiency | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.3) | 0 (0.0) |
Nausea | 1 (1.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.3) | 0 (0.0) |
