Fig. 1: Architecture of the GPR55-G13 signaling complex with lipid and synthetic agonists. | Nature Communications

Fig. 1: Architecture of the GPR55-G13 signaling complex with lipid and synthetic agonists.

From: Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55

Fig. 1: Architecture of the GPR55-G13 signaling complex with lipid and synthetic agonists.The alternative text for this image may have been generated using AI.

a Cryo-EM map (consensus, EMDB-51285) of the GPR55-Gα13β1γ2-ScFv16-LPI complex at two different contour levels. The enlarged cryo-EM map for LPI (yellow sticks) is shown in blue mesh. b Full model corresponding to the signaling complex of (a) (shown as cartoon representation). c Chemical structure of LPI. d Overview of ligand binding pocket position of LPI. e Cryo-EM map (consensus, EMDB-51281) of the GPR55-Gα13β1γ2-ScFv16-ML184 complex at two different contour levels. The enlarged cryo-EM map for ML184 (salmon sicks) is shown in blue mesh. f Full model corresponding to the signaling complex of (d). g Overview of ligand binding pocket position of ML184. The yellow circle highlights the position of the polar head group of LPI. h Chemical structure of ML184.

Back to article page