Fig. 3: Details of interactions between the NiV L-P complex and RNA. | Nature Communications

Fig. 3: Details of interactions between the NiV L-P complex and RNA.

From: Structural basis of Nipah virus RNA synthesis

Fig. 3: Details of interactions between the NiV L-P complex and RNA.

a Overall fold of the RdRp domain with the fingers, palm, and thumb subdomains colored and labeled as indicated. A close-up view of the active site shows the interactions between the RNA duplex and incoming NTP with motifs C and F. b Schematic of protein-RNA interactions. c Superposition of motif C in the apo- and elongating NiV L-P structures reveals a conformational change in the active site to accommodate the duplex RNA.

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