Fig. 8: L1 activity in cancer is not affected by germline TP53 mutations. | Nature Communications

Fig. 8: L1 activity in cancer is not affected by germline TP53 mutations.

From: Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency

Fig. 8

a Comparing L1 RT burden (top) and RNA expression (bottom) in tumors from patients with germline p53 mutations (N = 13, RT burden; N = 22, RNA expression) compared with bootstrap resampling controls of patients with somatic p53 mutations (N = 10,000 resamplings). p-Values are calculated from a two-sided t-test of bootstrapped values compared with true LFS samples. b 95% confidence intervals of the means of bootstrap resamplings, with the red dotted line representing the value for the true LFS sample set.

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