Fig. 2: GWAS of Testosterone levels and hypogonadism in MVP men. | Nature Communications

Fig. 2: GWAS of Testosterone levels and hypogonadism in MVP men.

From: Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men

Fig. 2: GWAS of Testosterone levels and hypogonadism in MVP men.The alternative text for this image may have been generated using AI.

Circos plot of METAL p-values (-log base 10) of GWAS for total testosterone, free testosterone, SHBG, and hypogonadism in the MVP. The green line indicates a suggestive threshold (p < 10−6), and the red line indicates a genome-wide significance threshold (p < 5 × 10−8). The gray band correspond to Cochran's Q statistic to measure heterogeneity. Genes implicated through colocalization analysis (PP H4 > 0.8) are labeled on the outer ring and colored by cell type localization signal: liver (yellow), adrenal gland (green), testes (orange), multiple cell types (purple). A complete list of associations and nearby genes can be found in Supplementary Data 6.

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