Fig. 3: Delayed clearance and altered biodistribution of AAV8 in Abcb4−/− mice.
From: Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytes
14-week-old male Abcb4−/− (n = 7) and Abcb4+/− (control, n = 6) mice were administered with 5 × 1012 gc/kg of AAV2/8-TBG-GFP vector and sacrificed 2 days post-injection. A Vector genome copy (GC) analysis in livers (P = 0.00002). B Vector GC analysis in the plasma and C quantification of the area under the curve (AUC) in Abcb4−/− (n = 14) and Abcb4+/− (control, n = 11) mice administered with AAV2/8-TBG-GFP. D Vector GC analysis in extra-hepatic organs from male Abcb4−/− (n = 8) and Abcb4+/− (control, n = 6) mice (two-tailed t-test or, B only, repeated measure two-way ANOVA plus Sidak post-hoc). Data are reported as mean ± standard error.
