Fig. 4: ADP reduces the β-actin dynamics.
From: Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors
A RMSF of ADP-Actin systems. Background colors correspond to subdomains (see Fig. 1). B Cleft(Å)-Dihedral(°) maps of ADP-bound actin systems. C Main hydrogen bonds between SD2 and SD4 subdomains for HIC73 system. D Volumes of active sites. E Distribution of the distance(Å) between magnesium ion and γ-phosphate. F Histograms of the number of water molecules around the magnesium (≤5 Å) in the active site. G Representation of three most represented allosteric paths between R62 and E207 in HIC73 system. H Licorice representation of the residues involved in the three main paths presented in (G). Pathways for HIS73 and HIC73 + Mg2+ systems are presented in Fig. S4. Statistical significance of differences has been assessed using a two-sided Kolmogorov–Smirnov test (Table S3).
