Fig. 9: Nanovaccines induce CD4+ T lymphocytes responses in ApoE−/− mice. | Nature Communications

Fig. 9: Nanovaccines induce CD4+ T lymphocytes responses in ApoE−/− mice.

From: A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models

Fig. 9: Nanovaccines induce CD4+ T lymphocytes responses in ApoE−/− mice.The alternative text for this image may have been generated using AI.

Flow cytometric analyses of spleen T lymphocytes from ApoE−/− mice at 10 weeks post vaccination for percentages of CD4+ T cells (a), CD4+CD25+ T cells (b), CD4+IL−10+ T cells (c). n = 3, 3, 4, and 4 for PBS, D + P, SP-D1P1, and SP-D1 + P1, respectively. Spleen T lymphocytes isolated from C57BL/6 mice at week 15 post-vaccination were labeled with CSFE and stimulated with p210 for 5 days and CD4+ (n = 3, 3, 4, and 4 for PBS, D + P, SP-D1P1, and SP-D1 + P1, respectively) (d) and CD8+ (n = 3 animals per group) (e) T cell proliferation was quantified. The data are shown as mean ± SD. Statistical significance was calculated by one-way ANOVA with Tukey’s test for post hoc analysis. Statistically significant p values are reported; ns means no significance. Source data are provided as a Source Data file.

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